![]() ![]() ![]() Ultrasound (US) examination showed simple cysts sized <1 cm in both breasts. Experimental group included 50 women with respective history data and clinical findings, existence of mastalgia and mastodynia, and premenstrual syndrome (PMS). The study was conducted at the Department of Endocrinology, Clinical Center Serbia, and included 90 women with regular MC, aged 20 to 40 years, with normal body mass index (BMI) and waist/hip (W/H) ratio. The study was aimed at assessing the correlation between the hormones and the disease, in order to alleviate discomfort with appropriate therapy and improve emotional stability of the woman. Regarding the incidence, suffering and fear caused by benign changes in the breasts, studying secretion of just these hormones in the late MC secretion phase seemed to be quite important. So far, very few studies monitored the relation of sexual ovary hormones in the late luteal phase, most often in the first 7 days after ovulation. These controversies emphasize the absence of negative correlation between steroid ovary hormones and the occurrence of benign diseases of the breasts ( 6, 7). Although some studies show how the prevalence of increased estrogen concentration during the menstrual cycle (MC) could be one of the main pathophysiological disorders ( 5), there are controversies found in the literature. Many researchers believe that changes in hormone status of prolactin, thyroid hormones and steroid ovary hormones may lead to development of benign changes in the breasts ( 4). It is noted that, even in women with healthy hygienic-diet regimen and no risk habits such as excessive consumption of coffee, opiates and smoking, the disease is still manifested. The treatment is still just empirical, which leads the scientists to search for the pathophysiological cause of the changes and estimate the malignant potential. The question is what causes the high incidence of these changes and how to ease the discomfort. In this period, her body is exposed to quite significant hormone turbulences ( 2- 4). Its highest incidence is between 20 and 50 years of age, when a woman is most exposed to stress periods, e.g., her development in the society, forming a family and giving birth. ![]() Even the slightest disturbance of the E2/P ratio may contribute to the occurrence of FBD with clinical manifestations of mastalgia and mastodynia.įibrocystic breast disease (FBD), recently called fibrocystic changes in the literature, is the most frequent benign breast disease, which is diagnosed in 50% of the clinically and 90% of the histopathologically examined women ( 1). In the control group, a reduced E2/P ratio was noticed from day 21 to day 24 of the cycle (from 14.8☑1.5 pg/mL to 9.1☖.1 pg/mL p<0.05), which was not recorded in the group of women with FBD (study group). FBD diagnosis was confirmed with ultrasound (size and number of simple cysts). Significant mastalgia and mastodynia history in women with FBD was obtained with yes or no questionnaire. Blood samples for estradiol (E2), progesterone (P) and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. The concentration of estradiol/progesterone was measured in the group of women with FBD as study group (n=50) and control group of women without FBD (n=40). SUMMARY – The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |